Insulins

Insulin Chart

Renal Function Medication Adjustment Chart

General info:

- Relative A1C lowering:

- Hypoglycemia: Yes

- Weight:

- Effect in cardiovascular outcome trial: Neutral

- Other therapeutic considerations: No dose ceiling, flexible regimens

- Cost: $ to $$$$


Coverage Color Legend

Provinces (Two-Letter Abbreviation)

= No information

= Product not available

= Covered

= Possible Private coverage

= Conditional public coverage
(Touch box for more details)


Insulins (Bolus)
Prandial

Aspart
Fiasp®
Onset of action: 4 min
Peak of action: 0.5 to 1.5 h
Duration of action: 3 to 5 h
Stability at room temperature: 28 days

Presentation

- Cartridge
- Vial
- Pre-filled insulin pen

Devices

- NovoPen® 4 and 5 (memory)
- NovoPen Echo® (0.5 un - memory)
- Fiasp® FlexTouch® (pre-filled)
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Aspart
NovoRapid®
Onset of action: 9 to 20 min
Peak of action: 1 to 1.5 h
Duration of action: 3 to 5 h
Stability at room temperature: 28 days
BC
SK

Presentation

- Cartridge
- Vial
- Pre-filled insulin pen

Devices

- NovoPen® 4 and 5 (memory)
- NovoPen Echo® (0.5 un - memory)
- Fiasp® FlexTouch® (pre-filled)
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Glulisine
Apidra®
Onset of action: 10 to 15 min
Peak of action: 1 to 1.5 h
Duration of action: 3.5 to 5 h
Stability at room temperature: 28 days
BC

Presentation

- Cartridge
- Vial
- Pre-filled insulin pen

Devices

- JuniorSTARTM (0.5 un)
- ClikSTAR®
- Apidra® SoloSTAR® (pre-filled)
- AllStarTM Pro
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Humalog U100
Humalog® U100
Onset of action: 10 to 15 min
Peak of action: 1 to 2 h
Duration of action: 3 to 4.75 h
Stability at room temperature: 28 days
BC NB NL
NS

Presentation

- Cartridge
- Vial (3 ml and 10 ml)
- Pre-filled insulin pen

Devices

- HumaPen LUXURA® HD (0.5 un)
- HumaPen SAVVIOTM
- Humalog® KwikPen® (pre-filled)
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Humalog U200
Humalog® U200
Onset of action: 10 to 15 min
Peak of action: 1 to 2 h
Duration of action: 3 to 4.75 h
Stability at room temperature: 28 days
NL

Presentation

- Pre-filled insulin pen

Device

- Humalog® KwikPen® 200 u/ml (pre-filled)
Caution: Do not transfer to a syringe. Severe overdose can result.
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Humulin R U500
EntuzityTM
Onset of action: 15 min
Peak of action: 4 to 8 h
Duration of action: 17 to 24 h
Stability at room temperature: 28 days

Presentation

- Pre-filled insulin pen

Device

- KwikPenTM 3 ml (Pre-filled insulin pen containing 1.500 units of insulin)
Caution: Do not transfer to a syringe. Severe overdose can result.
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Insulin Regular
Humulin®R
Onset of action: 30 min
Peak of action: 2 to 3 h
Duration of action: 6.5 h
Stability at room temperature: 28 days

Presentation

- Cartridge
- Vial
- Pre-filled insulin pen

Devices

- HumaPen LUXURA® HD (0.5 un)
- HumaPen SAVVIOTM
- Humulin® R KwikPen® (pre-filled)
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Insulin Regular
Novolin®ge Toronto
Onset of action: 30 min
Peak of action: 2 to 3 h
Duration of action: 6.5 h
Stability at room temperature: 28 days

Presentation

- Cartridge
- Vial

Devices

- NovoPen® 4 and 5 (memory)
- NovoPen Echo® (0.5 un - memory)
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

BASAL INSULINS

NPH
Humulin®N
Onset of action: 1 to 3 h
Peak of action: 5 to 8 h
Duration of action: Up to 18 h
Stability at room temperature: 28 days

Presentation

- Cartridge
- Vial
- Pre-filled insulin pen

Devices

- HumaPen LUXURA® HD (0.5 un)
- HumaPen SAVVIOTM
- Humulin® N KwikPen® (pre-filled)
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

NPH
Novolin®ge NPH
Onset of action: 1 to 3 h
Peak of action: 5 to 8 h
Duration of action: Up to 18 h
Stability at room temperature: 28 days

Presentation

- Cartridge
- Vial

Devices

- NovoPen® 4 and 5 (memory)
- NovoPen Echo® (0.5 un - memory)
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Degludec U100 and U200
Tresiba®
Onset of action: 90 min
Peak of action: No significant peak
Duration of action: Up to 42 h
Stability at room temperature: 56 days
"Switch" and adjustment

Presentation

- Pre-filled insulin pen

Devices

- Tresiba FlextouchTM (pre-filled) 100 U/ml and 200 U/ml
Caution: Do not transfer to a syringe. Severe overdose can result.
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Detemir
Levemir®
Onset of action: 90 min
Peak of action: No significant peak
Duration of action: 16 to 24 h
Stability at room temperature: 42 days
"Switch" and adjustment
BC NB NL
NS PE

Presentation

- Cartridge
- Pre-filled insulin pen

Devices

- NovoPen® 4 and 5 (memory)
- NovoPen Echo® (0.5 un - memory)
- Levemir® FlexTouch® (pre-filled)
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Glargine U100
Lantus®
Onset of action: 90 min
Peak of action: No significant peak
Duration of action: Up to 24 h
Stability at room temperature: 28 days
"Switch" and adjustment

NS PE

Presentation

- Cartridge
- Vial
- Pre-filled insulin pen

Devices

- JuniorSTARTM (0.5 un)
- ClikSTAR®
- Lantus® SoloSTAR® (pre-filled)
- AllStarTM Pro
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Glargine U100
Basaglar®
Onset of action: 90 min
Peak of action: No significant peak
Duration of action: Up to 24 h
Stability at room temperature: 28 days
"Switch" and adjustment
BC

Presentation

- Cartridge
- Vial

Devices

- Basaglar® KwikPen® (pre-filled)
- HumaPen SAVVIOTM
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Glargine U300
Toujeo®
Onset of action: 90 min
Peak of action: No significant peak
Duration of action: > 30 h
Stability at room temperature: 42 days
"Switch" and adjustment

PE

Device

- Toujeo® 300 u/ml SoloSTAR® (pre-filled) 1.5 ml = 450 units
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)
Caution: Do not transfer to a syringe. Severe overdose can result.

FIXED-RATIO COMBINATIONS

Glargine U100 (100 units/ml) / Lixisenatide (33 mcg/ml)
SoliquaTM
Maximum recommended daily dose is 60 units:
Glargine U100 60 units / Lixisenatide 20 mcg
Therapy Initiation and Titration

Device

- Stylo SoloSTAR® (pre-filled) 3 ml
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Degludec (100 units/ml) / Liraglutide (3.6 mg/ml)
Xultophy®
Maximum recommended daily dose is 50 units:
Degludec 50 units / Liraglutide 1.8 mg
Therapy Initiation and Titration
Coverage

Device

- Stylo Flextouch® (pre-filled) 3 ml
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

PREMIXED INSULINS
Medications - Injectable medications s/c

A single vial or cartridge contains a fixed ratio of insulin (% of rapid-acting or short-acting insulin to % of intermediate-acting insulin).

Humulin® 30/70
Humulin® 30/70

Presentation

- Cartridge
- Vial

Devices

- HumaPen LUXURA® HD (0.5 un)
- HumaPen SAVVIOTM
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Novolin®ge
30/70, 40/60, 50/50

Novolin® ge
30/70, 40/60, 50/50


Presentation

- Cartridge
- Vial (only for 30/70)

Devices

- NovoPen® 4 and 5 (memory)
- NovoPen Echo® (0.5 un - memory)
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Biphasic Insulin Aspart
NovoMix® 30
BC
QC

Presentation

- Cartridge

Devices

- NovoPen® 4 and 5 (memory)
- NovoPen Echo® (0.5 un - memory)
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Lispro Insulin
Lispro Protamine

Humalog® Mix25® and Mix50®
Mix25®
Mix50®
BC
QC

Presentation

- Cartridge
- Pre-filled insulin pen

Devices

- HumaPen LUXURA® HD (0.5 un)
- HumaPen KwikPen® Junior® (0.5 un)
- HumaPen SAVVIOTM
- Humalog® Mix25® KwikPen® (pre-filled)
- Humalog® Mix50® KwikPen® (pre-filled)
- 4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)