DISCLAIMER
The Diabetes Québec Toolbox is intended for Québec healthcare professionals only. By accessing this web application, you confirm that you are a healthcare professional. The information in the Toolbox is provided for general information purposes only and is not comprehensive. Under no circumstances can Diabetes Québec be held responsible for any error or omission or be prosecuted for any reason whatsoever.
Insulins
Chart Summary DQ (FR)

General info
- Relative A1C lowering:
- Hypoglycemia: Yes
- Weight:
- Effect in cardiovascular outcome trial: Neutral
- Other therapeutic considerations: No dose ceiling, flexible regimens
- Costt : $ to $$$$

INSULINS (Bolus)
Prandial

Aspart
Fiasp®

Onset of action: 4 min:
Peak of action: 0.5 to 1.5 h
Duration of action: 3 to 5 h
Stability at room temperature: 28 days
Not covered / Private coverage
Product Monograph Video demo. of the injection technic with the Flextouch Pen
Presentation
- Cartridge, Vial, Pre-filled insulin pen
Devices
- NovoPen® 4 and 5 (memory)
- NovoPen Echo® (0.5 un - memory)
- Fiasp® FlexTouch® (pre-filled)
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Aspart
NovoRapid®

Onset of action: 9 to 20 min
Peak of action: 1 to 1.5 h
Duration of action: 3 to 5 h
Stability at room temperature: 28 days
Non Covered / To be checked with private insurance
See Infolettre RAMQ
Product Monograph
Video demo. of the injection technic with the Flextouch Pen
Presentation
- Cartridge, Vial
Devices
- NovoPen® 4 and 5 (memory)
- NovoPen Echo® (0.5 un - memory)
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Aspart
Trurapi®
(Biosimilar)
Onset of action: 9 to 20 min
Peak of action: 1 to 1.5 h
Duration of action: 3 to 5 h
Stability at room temperature: 28 days
Covered
See Infolettre RAMQ
Product Monograph
Information Brochure
Presentation
- Cartridge, Pre-filled insulin pen
Devices
- JuniorSTAR™️ (0.5 un)
- ClikSTAR®
- Trurapi® SoloSTAR® (pre-filled)
- AllStar® Pro
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Aspart
Kirsty®
(Biosimilar)
Onset of action: 9 to 20 min
Peak of action: 1 to 1.5 h
Duration of action: 3 to 5 h
Stability at room temperature: 28 days
Covered
See Infolettre RAMQ
Product Monograph
Guide
Presentation
- Pre-filled insulin pen
Devices
- Pre-filled insulin pen only (looks like Sanofi's Solostar pre-filled pen)
*Warning. Both Kirsty and Semglee pens are the same color
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Glulisine
Apidra®

Onset of action: 10 to 15 min
Peak of action: 1 to 1.5 h
Duration of action: 3.5 to 5 h
Stability at room temperature: 28 days
Covered
Product Monograph
Presentation
- Cartridge, Vial, Pre-filled insulin pen
Devices
- JuniorSTAR™️ (0.5 un)
- ClikSTAR®
- Apidra® SoloSTAR® (pre-filled)
- AllStar® Pro
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Lispro
Humalog U100®

Onset of action: 10 to 15 min
Peak of action: 1 to 2 h
Duration of action: 3 to 4.75 h
Stability at room temperature: 28 days
Private Insurance / Conditional coverage
See Infolettre RAMQ
Product Monograph
Presentation
- Cartridge, Vial (3ml and 10ml), Pre-filled insulin pen
Devices
- HumaPen LUXURA® HD (0.5 un)
- HumaPen SAVVIOTM
- Humalog® KwikPen® (pre-filled)
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Lispro
Admelog®
(Biosimilar)
Onset of action: 10 to 15 min
Peak of action: 1 to 2h
Duration of action: 3 to 4.75 h
Stability at room temperature: 28 days
Covered
Product Monograph
Information Brochure
Your guide to getting started
Presentation
- Cartridge, Vial, Pre-filled insulin pen
Devices
- JuniorSTAR™️ (0.5 un)
- ClikSTAR®
- Admelog® SoloSTAR® (pre-filled)
- AllStar® Pro
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Lispro
Humalog® U200

Onset of action: 10 to 15 min
Peak of action: 1 to 2 h
Duration of action: 3 to 4.75 h
Stability at room temperature: 28 days
Covered
Product Monograph
Presentation
- Pre-filled insulin pen
Devices
- Humalog® 200 u/ml KwikPen® (pre-filled)
Caution: Do not transfer to a syringe. Severe overdose can result.
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Humulin R U500
EntuzityTM

Onset of action: 15 min
Peak of action: 4 to 8 h
Duration of action: 17 to 24 h
Stability at room temperature: 28 days
Covered
Product Monograph
Presentation
- Pre-filled insulin pen
Devices
- Humulin R 500 u/ml KwikPenM® (Pre-filled) 3 ml = 1500 units of insulin with an increment of 5 and a maximum of 160 units per injection
Caution: Do not transfer to a syringe. Severe overdose can result.
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Insulin Regular
Humulin®R

Onset of action: 30 min
Peak of action: 2 to 3 h
Duration of action: 6.5 h
Stability at room temperature: 28 days
Covered
Product Monograph
Presentation
-Cartridge, Vial, Pre-filled insulin pen
Devices
- HumaPen LUXURA® HD (0.5 un)
- HumaPen SAVVIOTM
- Humulin® R KwikPen® (pre-filled)
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Insulin Regular
Novolin®ge Toronto

Onset of action: 30 min
Peak of action: 2 to 3 h
Duration of action: 6.5 h
Stability at room temperature: 28 days
Covered
Product Monograph
Presentation
-Cartridge, Vial
Devices
- NovoPen® 4 and 5 (memory)
- NovoPen Echo® (0.5 un - memory)
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

BASAL INSULINS

NPH
Humulin®N

Onset of action: 1 to 3 h
Peak of action: 5 to 8 h
Duration of action: a 18 h
Stability at room temperature: 28 days
Covered
Product Monograph
Presentation
- Cartridge, Vial, Pre-filled insulin pen
Devices
- HumaPen LUXURA® HD (0.5 un)
- HumaPen SAVVIOTM
- Humulin® R KwikPen® (pre-filled)
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

NPH
Novolin®ge NPH

Onset of action: 1 to 3 h
Peak of action: 5 to 8 h
Duration of action: a 18 h
Stability at room temperature: 28 days
Covered
Product Monograph
Presentation
- Cartridge, Vial
Devices
- NovoPen® 4 and 5 (memory)
- NovoPen Echo® (0.5 un - memory)
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Degludec U100 and U200
Tresiba®

Onset of action: 90 min
Peak of action: No significant peak
Duration of action: a 42 h
Stability at room temperature: 56 days
Covered
Product Monograph
Video demo. of the injection technic with the Flextouch Pen
Initiation,Titration and Technic Patient Handout
Complete Guide for Virtual Care
Presentation
- Cartridge, Pre-filled insulin pen
Devices
- Tresiba Flextouch™️ (pre-filled) 3 ml 100 U/ml and 200 U/ml with an increment of 2 and a maximum of 160 units per injection
Caution: Do not transfer to a syringe. Severe overdose can result.
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Detemir
Levemir®

Onset of action: 90 min
Peak of action: No significant peak
Duration of action: 16 a 24 h
Stability at room temperature: 42 days
Covered (Cartridge only)
Product Monograph
Video demo. of the injection technic with the Flextouch Pen
"Switch" and adjustment
Presentation
- Cartridge
Devices
- NovoPen® 4 and 5 (memory)
- NovoPen Echo® (0.5 un - memory)
Caution: Do not transfer to a syringe. Severe overdose can result.
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Glargine U100
Lantus®

Onset of action: 90 min
Peak of action: No significant peak
Duration of action: to 24 h
Stability at room temperature: 28 days
Not covered / Private coverage
See Infolettre RAMQ
Product Monograph
"Switch" and adjustment
SUPPLY CONSTRAINTS FOR LANTUS ®SOLOSTAR ®(Insulin glargine) AND LANTUS ® CARTRIDGES (Insulin glargine)
Presentation
- Cartridge, Vial, Pre-filled insulin pen
Devices
- JuniorSTAR™️ (0.5 un)
- ClikSTAR®
- Lantus® SoloSTAR® (pre-filled)
- AllStar® Pro
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Glargine U100
BasaglarTM
(Biosimilar)
Onset of action: 90 min
Peak of action: No significant peak
Duration of action: to 24 h
Stability at room temperature: 28 days
Covered
Product Monograph
How to use the KwikPen®
Patient Teaching Guide
"Switch" and adjustment
Presentation
- Cartridge
Devices
- Basaglar™️ KwikPen® (pre-filled)
- HumaPen SAVVIO™️
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Glargine U100
SemgleeTM
(Biosimilar)
Onset of action: 90 min
Peak of action: No significant peak
Duration of action: to 24 h
Stability at room temperature: 28 days
Covered
Product Monograph
Guide
Presentation
- Pre-filled insulin pen
Devices
Pre-filled insulin pen only (looks like Sanofi's Solostar pre-filled pen)
*Warning. Both Kirsty and Semglee pens are the same color
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Glargine U300
ToujeoTM

Onset of action: 90 min
Peak of action: No significant peak
Duration of action: >30 h
Stability at room temperature: 42 days
Covered
Product Monograph
SoloSTAR® - Instructional Video®
DoubleSTAR® - Instructional Video®
"Switch" and adjustment
Devices
- Toujeo™️ 300 un/ml SoloSTAR® (pre-filled) 1.5 ml = 450 units
- Toujeo™️ 300 un/ml DoubleSTAR® (pre-filled) 3 ml = 900 units with an increment of 2 and a maximum of 160 units per injection
Caution: Do not transfer to a syringe. Severe overdose can result.
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Icodec
Awiqli®

Onset of action: 15 to 18 hours
Peak of action: Between the 2nd and 4th day of a week's cycle
Duration of action Half-life 1 week
Stability at room temperature: 12 weeks
Private coverage (when available)
Product Monograph
Presentation
- Pre-filled insulin pen
Devices
- Awiqli® Flextouch® 700 un/ml pre-filled pen 1 ml (700 units), 1.5 ml (1050 units) and 3 ml (2100 units)
(Increment of 10 and maximum dose per injection of 700 units)
*Caution: Do not transfer to a syringe. Severe overdose can result.
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

FIXED-RATIO COMBINATIONS

Glargine U100 (100 units/ml) / Lixisenatide (33 mcg/ml)
SoliquaTM

Maximum recommended daily dose is 60 units:
Glargine U100 60 units / Lixisenatide 20 mcg
Not covered / Private coverage
Product Monograph
How to Inject (video)
How to Inject
Therapy Initiation and Titration
Devices
- Stylo SoloSTAR® (pre-filled) 3 ml
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Degludec (100 units/ml) / Liraglutide (3.6mg/ml)
Xultophy®

Maximum recommended daily dose is 50 units:
Degludec 50 units / Liraglutide 1.8 mg
Not covered / Private coverage
Product Monograph
Therapy Initiation and Titration
Devices
- Stylo Flextouch® (pre-filled) 3 ml
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

PREMIXED INSULINS
Medications - Injectable medications s/c
Action: A single vial or cartridge contains a fixed ratio of insulin (% of rapid-acting or short-acting insulin to % of intermediate-acting insulin).

HumulinTM30/70
Covered
Product Monograph
Presentation
- Cartridge, Vial
Devices
- HumaPen LUXURA® HD (0.5 un)
- HumaPen SAVVIO™️
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Novolin®30/70
Covered
Product Monograph
Presentation
- Cartridge, Vial
Devices
- NovoPen® 4 and 5 (memory)
- NovoPen Echo® (0.5 un - memory)
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Insuline asparte biphasique
NovoMix®30
Code EN22
Product Monograph
Presentation
- Cartridge
Devices
- NovoPen® 4 and 5 (memory)
- NovoPen Echo® (0.5 un - memory)
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)

Insuline lispro
Lispro protamine
Humalog®Mix25® and Mix50®

Mix25®
Code EN22
Mix50®
Not covered / Private coverage
Product Monograph
Presentation
- Cartridge, Pre-filled insulin pen
Devices
- HumaPen LUXURA® HD (0.5 un)
- HumaPen SAVVIOTM
- Humalog® Mix25® KwikPen® (pre-filled)
- Humalog® Mix50® KwikPen® (pre-filled)
4, 5 and 6 mm pen needles are suitable for all people living with diabetes regardless of BMI. (Ref. Fit Canada)